By David C. Aron (auth.), Brooke Swearingen, Beverly M. K. Biller (eds.)
In Cushing’s ailment, major professionals within the box supply an intensive assessment of the pathogenesis, diagnostic set of rules and therapies for this advanced disorder. starting with a desirable heritage of Cushing's affliction that outlines its old importance to either endocrinology and neurosurgery, the e-book is going onto to hide the total diversity of significant matters, together with the molecular pathogenesis of Cushing’s, anatomic pathology, the prognosis of Cushing's syndrome, the differential of pseudo-Cushing's syndromes, hypercortisolemia, surgical removing of the corticotroph adenoma, post-operative administration and evaluation of remission, radiotherapeutic thoughts, and the fascinating advancements in scientific remedy. furthermore, the booklet additionally addresses Cushing's disorder within the pediatric inhabitants, provided that its medical manifestations and influence on progress may be critical; silent corticotroph adenomas as a unique scientific entity; prognosis and administration of Cushing's illness while pregnant, bilateral adrenalectomy, and, eventually, the long term mental manifestations of hypercortisolemia. finished and a useful addition the literature, Cushing’s ailment is a vital reference for reinforcing prognosis and therapy of this debilitating disorder.
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In our institution, the cytologic smears are often made intraoperatively by the neurosurgeon, fixed in ethanol, and sent to the frozen lab for staining and interpretation.
T. Hedley-Whyte made but have been inconclusive. 5, and 1%, respectively) [21, 22]. However, one should be aware that there is a considerable case-to-case variability of Ki-67 LI (0–22%) in pituitary carcinomas and also a great overlap between carcinomas and adenomas [3, 19]. Although assessment of Ki-67 LI does not allow one to diagnose pituitary carcinoma, a high LI greater than 10% should raise a suspicion about the malignant potential of the tumor . Overexpression of p53 protein has been detected in both pituitary adenomas and carcinomas but the frequency varies.
2008;75(4):279–83. 53. Tilney N. Harvey Cushing and the surgical research laboratory. Neurosurgery. 1980;151: 263–70. 54. Tilney N. Harvey Cushing and the evolution of a polymath. Surg Gyn Obstet. 1986;162:285–90. 55. Cushing H. The binding influence of a library on a subdiving profession in The Medical Career and Other Papers. ; 1940. 56. Albright F. Presidential Address to the American Society for Clinical Investigation, Atlantic City, New Jersey, 8 May 1944. Some of the “do’s” and “do-not’s” of clinical investigation.