By Ciba Foundation Symposium on Transplantation, G E. W. Wolstenholme, Margaret P Cameron
Chapter 1 beginning comments (pages 1–5): P. B. Medawar
Chapter 2 reports on Transplantation Antigens (pages 6–24): L. Brent, P. B. Medawar and M. Ruszkiewicz
Chapter three Transplantation Antigens, creation of Haemagglutinins and Inhibition of the Haemagglutination response (pages 25–44): G. Lejeune?Ledant
Chapter four H?2 Histocompatibility Antigens of the Mouse (pages 45–71): D. A. L. Davies
Chapter five An Isoantigenic Lipoprotein from Sarcoma I (pages 72–89): A. A. Kandutsch and Jack H. Stimpfling
Chapter 6 experiences on Cheek Pouch epidermis Homografts within the Syrian Hamster (pages 90–117): R. E. Billingham and Willys ok. Silvers
Chapter 7 Mother?Foetus Immunological Relation?Ship as a superb. Homograft version (pages 118–137): M. Hasek, V. Haskova and M. Vojtiskova
Chapter eight Transplantation Tolerance and Immunity in terms of Age (pages 138–162): J. G. Howard, Donald Michie and M. F. A. Woodruff
Chapter nine Immunogenetics of Tumours Grown in Radiation Chimeras (pages 163–184): Michael Feldman and David Yaffe
Chapter 10 The issue of Immunization: Clonal choice thought Investigated by means of Spleen Assays of Graft?Versus?Host response (pages 185–215): Morten Simonsen
Chapter eleven additional reports on Interactions among Graft Reactions Sessile and Humoral Antibodies in Homo?Graft Reactions (pages 216–235): J. R. Batchelor and M. S. Silverman
Chapter 12 Immunological Competence of Small Lymphocytes within the Graft?Versus?Host response in Mice (pages 236–270): W. H. Hildemann, W. D. Linscott and M. J. Morlino
Chapter thirteen Homograft Sensitivity in humans (pages 271–285): H. S. Lawrence, T. Rapaport and J. M. Converse
Chapter 14 safety opposed to Runting by way of particular remedy of baby Mice, through elevated Tolerance (pages 286–327): man A. Voisin and Radslav Kinsky
Chapter 15 Induction of particular Tolerance in grownup Rats by way of the strategy of Parabiosis (pages 328–349): B. Nakic, A. Kastelan and N. Avdalovic
Chapter sixteen amendment of Runt disorder in Mice by means of quite a few capability (pages 350–383): Paul S. Russell
Chapter 17 position of the Thymus in Transplantation Tolerance and Immunity (pages 384–410): J. F. A. P. Miller
Chapter 18 Chairman's remaining feedback (pages 411–412):
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Additional resources for Ciba Foundation Symposium - Transplantation
Indeed, there is no inhibition when isologous extracts are used. 3’ G. L E J E U N E - L E D A N T On the other hand, all the extracts prepared according to the methods of preparation of the blood group substances, which, instead of producing a transplantation immunity, give a prolonged survival of the homografts of the same donor, all these extracts may be able to idubit the haemagglutination reaction. However, both these phenomena show a total lack of specificity. Table 111 HAEM AGGLUTINATION INHIBITION TEST WITH EPIDERMAL CELL-FRB EXTRACTS CBA red cells Cotitrol Serum I.
Amos: I don’t know if I can answer that completely. Dr. Billingham, in the rat, how many of these other systems also show up with haemagglutinating antibodies ? N. and Lewis rat strains we know that there are at least 16 dderent histocompatibility loci in this species, of which 4 appear to be of major status (Billingham, R. , Hodge, B. , and Silvers, W. K. . PYOC. nat. Acud. Sci. ), in press). Dr. Joy Palm has recently reviewed the current status of knowledge of blood groups in the rat (“Blood Groups in Infra-Human Species,” in Ann.
Silvers: We have attempted to induce tolerance of the Y factor with red cell preparations. Whereas as few as ~00,000leucocytes will consistently induce tolerance of the Y factor on inoculation into neonatal female recipients, the results with much higher dosages of erythrocyte preparations are extremely variable. As many as 100 million red cells 40 DISCUSSION may sometimes give tolerance and we are convinced that t h s is due to contamination of our red cell preparations with leucocytes. We are, therefore, of the opinion that tolerance of skin cannot be induced with erythrocytes in mammals.