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A accomplished evaluation of present considering at the biosynthesis, functionality and evolution of secondary metabolites in animals, crops and microorganisms. Examines the normal context of secondary metabolites as ordinary items having no seen half to play within the generating organism's existence cycle. Covers matters on the topic of genetic and antibiotic purposes.

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Ciba Foundation Symposium 171 - Secondary Metabolites: their Function and Evolution

A complete evaluation of present pondering at the biosynthesis, functionality and evolution of secondary metabolites in animals, crops and microorganisms. Examines the normal context of secondary metabolites as normal items having no seen half to play within the generating organism's lifestyles cycle. Covers concerns with regards to genetic and antibiotic purposes.

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Extra resources for Ciba Foundation Symposium 171 - Secondary Metabolites: their Function and Evolution

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Davies: There seems little doubt that there is a relationship between the origin of ribozymes and the formation of ribosomes. Harry Noller (personal communication) has extracted RNA from the 50s subunit of the ribosomes of a thermophilic bacterium and shown that this 23s RNA molecule catalyses the formation of peptide bonds. He demonstrated inhibition of this reaction by several antibiotics, known to inhibit peptide bond formation. It would be interesting to ask if one can get ribozymes to make peptide bonds.

As larger polypeptides are produced, certain of them remain associated with the ribosomal ribozyme, which permits more effective catalysis of Evolution of secondary metabolite production 27 peptide bond formation (ribosomal proteins are believed to be essentially involved in stabilization of the structure of the ribosome: Noller & Woese 1981). The RNA-binding peptides are assumed to be more efficient than the low molecular size effectors and displace the latter, generating a pro-ribosome. 5. The ribosome evolves to become a macromolecular RNA-protein complex which has improved capabilities for translation and for the production of larger polypeptides.

If you take a favourite molecule, formaldehyde, and polymerize it, you get about 30 known sugars and a large number of molecules you can’t identify. Among the products, ribose is represented maybe at the level of 2%. If you looked at the disaccharides, they would be made up from all these monosaccharides. 05% of any one of them. By the time you get to a trisaccharide with an amine here and a guinidine there, would be an optimistic view of the yield you could get. So if these aminoglycosides were there early on, they weren’t made as random structures out of the prebiotic soup; they were made as a consequence of the evolution of complex catalysts in the soup.

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