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Comprises the shows and discussions that happened in the course of a symposium on the CIBA starting place on October 1-3, 1990 near to catalytic antibodies. the popularity that monoclonal antibodies can own catalytic job is a up to date boost with profound ramifications for chemistry. as well as their power advertisement purposes as catalysts for reactions, for which there aren't any identified enzymes, antibodies promise to supply necessary perception into the special mechanisms of organic catalysis and natural chemistry.


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Coordinates of McPC603, HyHEL-5 and HyHEL-10 are taken from the Brookhaven Databank. 3 by Drs Simon Phillips and Roberto Poljak, and those for NC41 by Drs Peter Colman and Bill Tulip. The B1312, 17/9 and DB3 coordinates are from our laboratory. 5, Alzari et a1 1990), are well advanced, as are the structures of many other interesting Fab fragments and Fab complexes. Past experience has shown that it is always dangerous to generalize about antibody structures, but some basic features are already apparent.

36 Discussion Schwubucher: Another possible reason for flexibility in some of these molecules is that if there were a very rigid binding pocket exactly complementary to the target molecule, there could be slow binding of the product in the pocket. Such a pocket might also allow anything small enough and hydrophobic to bind. If the binding pocket were able to close up somewhat, it would increase selectivity at the expense of losing some affinity for the hapten. Suckling: How much does the conformation of an antibody change as a function of pH?

The same is true of hydrazine, but the thiol-substituted compound works, albeit poorly. Lerner: If one could get the second order rate constant, it would be interesting to see how close it approached the theoretical value. Without a second order rate constant, how could you estimate the effect of molarity? Page: You could measure the rate constant of the reverse reaction, the hydrolysis, then if you knew the equilibrium constants, you could calculate the second order rate constant. Schultz: Or you could make use of radioactively labelled compounds.

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