By Douglas P. Zipes MD, Jose Jalife MD
Cardiac Electrophysiology: From phone to Bedside defines the full nation of present clinical and medical wisdom during this subspecialty. according to the various significant contemporary advancements within the box, Drs. Zipes and Jalife have thoroughly up to date this contemporary vintage, making the fifth variation the main major revision but. From our most modern figuring out of ion channels, molecular genetics, and cardiac electric task via newly well-known syndromes, exact wishes of targeted sufferer populations, and new diagnostic and healing thoughts, you will discover the entire state of the art information you must make knowledgeable, powerful scientific judgements. what is extra, a considerably restructured association, a brand new full-color format, and full-text on-line entry make reference more uncomplicated than ever.Integrates the newest clinical realizing of arrhythmias with the latest scientific purposes, supplying you with an educated foundation for selecting the precise remedy and administration concepts for every patient.Synthesizes the information of preeminent gurus in cardiology, body structure, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgical procedure, and biomedical engineering from around the globe, supplying you with a well-rounded, specialist clutch of each factor that has effects on your sufferer management.Contains 24 new chapters (listed less than) in addition to exhaustive updates all through, to maintain you present with new medical wisdom, newly came upon arrhythmia syndromes, and new diagnostic and healing techniques.Developmental law of Cardiac Ion ChannelsNeural Mechanisms of beginning and preserving ArrhythmiasSingle Nucleotide Polymorphisms and bought Cardiac ArrhythmiasInheritable Sodium Channel DiseasesInheritable Potassium Channel DiseasesInheritable ailments of Intracellular Calcium RegulationMorphological Correlates of Atrial ArrhythmiasAndersen-Tawil SyndromeTimothy SyndromeProgressive Cardiac Conduction DiseaseSudden little one loss of life SyndromeArrhythmias in sufferers with Neurologic DisordersAutonomic TestingCardiac Resynchronization TherapyEnergy resources for Catheter AblationLinear Lesions to Ablate Atrial FibrillationCatheter Ablation of Ventricular Arrhythmias in sufferers with Structural center DiseaseCatheter Ablation of Ventricular Arrhythmias in sufferers with out Structural middle DiseaseCatheter Ablation in sufferers with Congenital middle DiseaseFeatures a very new part on "Arrhythmias in particular Populations" that explores arrhythmias in athletes ... gender adjustments in arrhythmias ... arrhythmias in pediatric sufferers ... and sleep-disordered respiring and arrhythmias.Offers an enticing new full-color layout that includes colour pictures, tables, movement charts, ECGs, and extra, making clinically actionable info effortless to discover and take up at a glance.Includes full-text on-line entry through professional seek advice, making reference more straightforward for busy practitioners.Your buy entitles you to entry the website till the subsequent version is released, or till the present version is not any longer provided on the market by way of Elsevier, whichever happens first. If the subsequent version is released under 12 months after your buy, you can be entitled to on-line entry for three hundred and sixty five days out of your date of buy. Elsevier reserves the fitting to supply an appropriate substitute product (such as a downloadable or CD-ROM-based digital model) should still on-line entry to the website be discontinued.
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Additional info for Cardiac Electrophysiology: From Cell to Bedside: Expert Consult - Online and Print, Fifth Edition
J Biol Chem 274:26511-26517, 1999. 18. Chen C, Bharucha V, Chen Y, et al: Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel b2-subunits. Proc Natl Acad Sci USA 99:17072-17077, 2002. 19. Chen C, Westenbroek E, Xu X, et al: Mice lacking sodium channel b1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci 24:40304042, 2004. 20. Lopez-Santiago LF, Meadows L, Ernst SJ, et al: Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.
The SR Ca2+ release channels that are activated by transsarcolemmal Ca2+ influx are described in Chapter 6. 1-4 Calcium Channel Types At least 10 calcium channel genes are recognized, designated by several different nomenclatures (Fig. 2-1). , at more positive membrane potential, Em). T-type calcium channels are characterized by a smaller single-channel conductance (approximately 8 pS in 110 mM barium), more transient openings, insensitivity to DHPs, and activation at more negative Em. Further distinctions among L- and T-type calcium channels in heart are recognized: L-type calcium current (ICa) is due mainly to a1C (and, to a lesser extent, a1D), and T-type ICa is due to a1G and a1H.
Proc Natl Acad Sci USA 86:8170-8174, 1989. 74. Satin J, Kyle JW, Chen M, et al: A mutant of TTX-resistant cardiac sodium channels with TTX-sensitive properties. Science 256:1202-1205, 1992. 75. Sivilotti L, Okuse K, Akopian AN, et al: A single serine residue confers tetrodotoxin insensitivity on the rat sensory-neuron-specific sodium channel SNS. FEBS Lett 409:49-52, 1997. 76. Hiyama TY, Watanabe E, Okado H, Noda M: The subfornical organ is the primary locus of sodium-level sensing by Nax sodium channels for the control of salt-intake behavior.