By Eric Beitz
The aquaporin box has matured at a really speedy speed and we're on the verge to improve severe thoughts to therapeutically modulate aquaporin functionality without delay or through regulatory networks. Key necessities can be found this day: i. a substantial (and becoming) variety of aquaporin crystal buildings for the rational layout of inhibitory molecules, ii. complicated molecular dynamics simulation recommendations for theoretical analyses of selectivity mechanisms and docking experiments, iii. complete facts on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological experiences, and v. assay structures for compound library screenings. The constitution of this quantity on aquaporins follows the issues laid out above and therefore covers the advancements from uncomplicated learn to strength pharmacological use. positioned among pharmacology textbooks and up to date clinical papers this publication presents a well timed evaluation for readers from the elemental in addition to the utilized disciplines.
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Additional resources for Aquaporins (Handbook of Experimental Pharmacology, Volume 190)
Mouse red blood cells express AQP9 in contrast to human and rat red blood cells that express AQP3. Red blood cells from AQP9 null mice have dramatically reduced glycerol permeability but the water permeability remains unchanged (Liu et al. 2007). The physiological role for AQP9 in red blood cells is not clear. Red blood cells are invaded during malarial infection. Glycerol has been shown to be used by Plasmodium, the parasite that causes malaria, for lipid biogenesis and as an energy source (Vial et al.
2005). Another group found the same adult-onset obesity and found that the AQP7 null mice became insulin resistant after being fed a high-fat and high-sucrose diet. In addition there was increased glycerol kinase enzymatic activity that the authors propose is responsible for the increased storage of triglycerides in the adipocytes of the AQP7 null mice (Hibuse et al. 2005). AQP7 is being investigated in human subjects. One study compared AQP7 transcript abundance in the adipose tissue of two groups of patients.
5 Perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 33 36 37 38 38 41 45 45 48 49 50 51 51 Abstract Progress in the structure determination of AQPs has led to a deep understanding of water and solute permeation by these small integral membrane proteins.