By Carlos Olano, Carmen Méndez, José A. Salas (auth.), Tomás G. Villa, Patricia Veiga-Crespo (eds.)
Since penicillin and salvarsan have been found, a few new medicines to wrestle infectious ailments were built, yet even as, the variety of multi-resistant microorganism lines is expanding. therefore, the layout of recent and potent antibacterial, antiviral and antifungal brokers might be a huge problem within the subsequent years.
This booklet stories the present state of the art in antimicrobial examine and discusses new ideas for the layout and discovery of novel cures. issues coated contain using genetic engineering, genome mining, manipulation of gene clusters, X-ray and neutron scattering in addition to the antimicrobial results of crucial oils, antimicrobial brokers of plant foundation, beta-lactam antibiotics, antimicrobial peptides, and cell-wall-affecting antifungal antibiotics.
Read Online or Download Antimicrobial Compounds: Current Strategies and New Alternatives PDF
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Additional resources for Antimicrobial Compounds: Current Strategies and New Alternatives
In: Dyson P (ed) Streptomyces molecular biology and biotechnology, 1st edn. Caiser Academic Press, Norfolk, pp 195–232 Onaka H, Mori Y, Igarashi Y et al (2011) Mycolic acid-containing bacteria induce naturalproduct biosynthesis in Streptomyces species. Appl Environ Microbiol 77:400–406 Ou X, Zhang B, Zhang L et al (2009) Characterization of rrdA, a TetR family protein gene involved in the regulation of secondary metabolism in Streptomyces coelicolor. Appl Environ Microbiol 75:2158–2165 Palaniappan N, Ayers S, Gupta S et al (2006) Production of hygromycin A analogs in Streptomyces hygroscopicus NRRL2388 through identification and manipulation of the biosynthetic gene cluster.
Once each biosynthesis cluster is associated to its corresponding compound, the use of combinatorial biosynthesis approaches will generate further structural diversity, increasing the arsenal of novel drugs. In addition, the biosynthesis gene clusters contain elements that can be used to increase the production of both natural and engineered products that will facilitate the reduction in production costs and in turn their commercial use. Acknowledgments Research at the authors’ laboratory has been supported by grants from Spanish Ministry of Science and Innovation (BIO2008-00269 to C.
Antimicrob Resist Infect Control 1:11 Carlson JC, Li S, Gunatilleke SS et al (2011) Tirandamycin biosynthesis is mediated by codependent oxidative enzymes. Nat Chem 3:628–633 Chen LF, Kaye D (2011) Current use for old antibacterial agents: polymyxins, rifamycins, and aminoglycosides. Med Clin North Am 95:819–842 Claesen J, Bibb M (2010) Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of post translationally modified peptides. Proc Natl Acad Sci USA 107:16297–16302 Craney A, Ozimok C, Pimentel-Elardo SM et al (2012) Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism.